Amand A. Lucas
Une fascination pour la double hélice
Simulations optiques de la diffraction des rayons X par l’ADN
Reference 9
Version 1
Date 24/10/2013
Article
Introduction
Sixty years after the discovery of the double helix structure of DNA, this iconic symbol of 20th century science continues to fascinate the world. The method of X-ray diffraction for structure determination played a crucial role in the discovery. Unfortunately the original, technical articles remain accessible only to specialized crystallographers. However this need not be so. In the present article we explain the structural meaning of the two X-ray diffraction images of the DNA molecule in its two A and B conformations in a language accessible to a large public. These were the two images which, among many other informations, have substantially helped Crick and Watson to discover both the double helix structure and the mechanism of its genetic function. In view of understanding the content of these two images in terms of molecular structure, we present the results of optical simulation experiments which allow to elucidate which aspect of the molecule corresponds to each of the features of the X-ray patterns.
Authors
Amand A. Lucas
Né à Liège le 18 décembre 1936. Membre titulaire de la Classe des Sciences. Élu correspondant le 4 janvier 1986 ; membre le 11 janvier 1992. Directeur de sa Classe en 1998. Devenu membre émérite le 3 juin 2021.Docteur en science physique.Professeur émérite des Universités de Liège et de Namur.Prix Francqui 1985.Membre de l'Academia Europaea
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